Computer Freezing.
Problem: For the past couple of weeks, I've had some freezing issues. It infrequently occurs after periods of long use (6+ hours). The display will no longer respond to any input. The mouse will still move but won't open or close any application. I cannot open task manager or do anything. I then have to force shut off on the computer in order to restart. There hasn't been any BSOD or Random shutoffs. Given the infrequency, it is impossible to replicate or predict.
So far it has occurred when:
Watching Netflix on Microsoft edge (x2). opening a game (x1), web surfing on chrome (x1), Steam uploading cloud saves (x1).
Background: The only noteworthy change prior to the issue was that I installed a new CPU cooler (specs below). The issue started a few days later, so I'm not sure if its related. Temps have been good so I don't think its overheating, especially since there are no issues while gaming, and only happening during light usage. I made sure it was only hand-tightened and there are no obvious signs of damage to motherboard.
Specs
OS: Windows 10
CPU: Ryzen 3600 (not OC)
Cooler: Cooler Master Hyper 212 Black RGB (previous cooler was stock AMD Wraith)
GPU: MSI GeForce RTX 3070 8 GB GAMING X TRIO
mb: MSI B550 A PRO
RAM: OLOy WarHawk RGB 32 GB RAM (3600)
Storage: Crucial P1 1 TB M.2-2280 NVME SSD. + Seagate Barracuda Compute 2 TB HDD (HDD not in use currently).
PSU: EVGA SuperNOVA GA 650 W 80+ Gold Certified Fully Modular ATX Power Supply
I built my computer about a month ago, so I wouldn't think its a hardware problem.
What I've tried so far: Ran both system file checker and DISM scan (one was found in sfc and repaired but issue persists). I've checked for new drivers but it appears everything is up-to-date. I've checked the event viewer but doesn't show anything obvious. I've ran a memtest which completed without any issues. I rolled back my graphics driver. I've ran anti-malware/virus security. Yet, the issue persists.
It has been extremely frustrating trying to troubleshoot this. Any experience/knowledge on this problem?

Comments
We are sorry about the issue you are having, but we can look into this for you. First question the Barracuda you listed as not in use currently, is it still connected to system? It is possible the secondary drive could be causing this. Disconnect it to rule it out entirely. If you are able to reinstall Windows, you would be able to narrow that down to either a software or hardware issue then. Based on how you described it I would think it is the drive, if you re-install Windows it would be worth it to do so on the Seagate. That will rule out the primary drive as being faulty or failing.
Also, I do remember switching sata ports for the barracuda when putting my computer back together after installing the cpu cooler. Can switching SATA ports cause problems? I will disconnect it to see if it could be the culprit.
I will reseat RAM and GPU and see if it persists. The most annoying part is that I cannot predict it, but seems to happen after running for more than 5 hours.
It's possible. I'd grab another peripheral cable and put the HDD on it's own line, or disconnect the hub temporarily to test. Your event viewer logs fit for the issue. If the drive is unresponsive, you won't be able to write logs, even if a secondary drive is causing the 'hang'. Now if the drive is not in use, has nothing installed to call the drive. Isn't being used for the page file or anything of that nature, it's very likely the cause is the combination of two devices.
Any suggestions on how to move forward?