Greetings. What specific parts were you looking to cool?
I would look over our guide for this, further information would depend on what type of liquid cooling you were looking to do:
Assuming you mean a custom water loop. They're mainly for heavy overclocking, for the anesthetics or both. If you're not overclocking, functionally it's not wise. Although with a 5950X, I'd recommend a 360MM AIO. Beyond that, you're going to hit the 142W PPT wall before you run into thermal issues when you are overclocking with a solid AIO. Ryzen overclocking is a bit different, as it's about undervolting the CPU rather than overvolting it, but that's another discussion.
As for maintenance. You're still going to have case fans, dust will be the same. For maintenance, it's higher with a custom loop. Needs to be drained and refilled probably twice a year. Build in a drain for this to make it less of a hassle. Set your radiator up vertically, that'll help as well with making this painless.
You're welcome, please let us know if you have any other questions !
You want at least a 240mm radiator for the cpu and a 360mm radiator if you overclock it. the GPU will need a 360mm aio and an active cooled backplate to go full loaf 24/7 and not degrade ever over time. them GDDR6 HBM mem chips on the back get real toasty. good luck on the build!
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